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John Hussman: Cracking the autism code

John Hussman lives by research. It's how he analyzed markets as an economics professor. It's how he returned 5% annually over the past decade (and beat the S&P 500) at his eponymous $6 billion mutual fund. It's how he predicted a recession in late 2007 (and why he thinks stocks are overpriced today ). And it's how he's attacking an unusual adversary for a fund manager: autism.

Over the past 15 years Hussman, 48, has thrown himself into understanding the disorder -- ever since his son, J.P., was diagnosed with it as a child. Because the vast majority of cases show a family link (a relative on J.P.'s mother's side is autistic), Hussman has focused on its genetic causes. Almost completely self-taught, he's spent nights and family vacations poring over obscure scientific textbooks (he says he's Amazon.com's best customer) and research abstracts. He not only funded a genomics center at the University of Miami , but has spent years collaborating with scientists there. published his findings in a paper that top researchers are calling a breakthrough. The dense, 16-page article features Ph.D.-level mathematics and abstruse genetic analyses. (We'll spare you the details, but you can check it out here .)

"I found it really interesting," says Dan Geschwind, a leading autism researcher at UCLA's School of Medicine. Joseph Buxbaum, another top researcher at Mount Sinai School of Medicine, says, "People are beginning to think about other areas where the mathematics and statistics have really evolved, and then bringing them back to genetics. This is a really neat example." Buxbaum himself is using methods borrowed from astrophysics to research autism.

Hussman's advance, researchers say, consists of the patterns he has found across hundreds of autism cases. Each person is the result of millions of genetic coin flips that occur across the human genome. Hussman's algorithm can detect unusual clusters of flips that may be linked to autism. There's a second benefit too. If you look at each coin flip separately to find the ones causing autism, you miss something because the flips are interconnected by genetic material -- one flip can influence another. Until now, autism researchers haven't been able to fully incorporate that influence into their research. Hussman created a way to do that, using complex statistics he learned from studying markets. "In finance, when you see the same signal across two different markets or countries, you take that as a stronger signal of information than if you only saw that signal in one market," he says. "It's similar in genetics.

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3 of 3 people found the following review helpful:

Miracle For My Face!!!!! , October 15, 2010

By  ilovelucy74 –

This review is from: Esoterica Fade Cream Regular (Night Time) – 2.5 Oz (Health and Beauty)

This stuff is great. I have had a stain on my face from Birth Control for the past 3 or 4 years. I dont have alot of money for a dermatologist and I have read alot about what an actual Dr. would prescribe even if I did go to one. Basically they would give you a prescription strength fade cream with the same active ingredient as Esoterica (hydroquinone) at 4% (maximum allowed by FDA in the US). Esoterica is 2%. Because I am a skeptic by nature, I had not purchased it until now, even though it is NOT expensive. I picked it up at Walmart for $6.99 and CVS carries it for a little more, not bad at all. I only found the night cream which suits me just fine. People would tell me that the stain on my face made me look as if someone punched me! It was blackish/greyish/purplish. HORRIBLE. I am 36 and look relatively young. I still get carded when I go out and this THING on my face had me feeling very insecure, undesirable, and unattractive. I would not leave my house without GLOBS of makeup that wound up clogging my pores and causing breakouts. Talk about vicious cycle. So about a week ago I pick this up and decided to give it a go. AMAZING. Within ONE DAY I noticed a difference. Now I am fair yellow/ivory complected. Warm skin tones. I have freckles and some acne scarring. Age and abuse from sun as well. This stuff is clearing it all up! The stain has been reduced to nearly invisible in just a week. You use very little product twice a day. I usually do it when I wash my face when I get home from being out, and before bed. Thats it. The acne scars were pretty dark too. They are almost gone. As a matter of fact, my overall facial texture appears brighter and younger. I will warn you, this may dry your skin out. What I had to do is take a day off. Exfoliate the dry skin on my face with a rich face scrub. Again I picked up a cheap one from Swiss Ives (apricot scrub). It left my skin feeling like a babies butt. Use common sense, exfoliate, moisturize, wear sunscreen during the day! You are treating your skin! Help the fade cream do its job! All of these help the overall polish of your skin in conjunction with the cream! I have VERY sensitive skin, and once I exfoliated with a moisture rich product my skin was better. I did let my skin repair for a day and overcome the dryness. A small price to pay in my opinion! It was just a little dry and itchy, but nothing you cannot avoid by doing a patch test a few days in a row! The sun damage on my forehead from the summer sun burn I got is almost completely gone too! But most importantly, the HUGE dark patch on my cheek is almost gone. Again, I had been asked if I hurt myself, had been punched, burned, or was CRYING (patch ran toward my EYES and looked like I cried while wearing mascara) THATS how dark that thing was! I could not be HAPPIER and I had to let everyone know. I havent even made a DENT in the small container of this product, you apply very sparingly! By the way, the acne stopped too! I have GREAT glowing baby skin and now I am wearing almost ZERO foundation. Compliments are coming left and right! I am also using it on my neck too to have uniform color and to get rid of darker patches of skin where I scratch when I get allergies. For those of you using it once a day or sporadically, step it up! Do it twice a day, you will be SO happy with the results! My self esteem is back and I will ALWAYS thank Esoterica, and teach my daughter the beauties of fade cream! Amazing how our grandma probably used this type of cream (remember gramma’s soft, milky skin?) Thank you for reading this and I hope you try Esoterica and have the SUCCESS I have had with it!!!!!! Good Luck!!!!!

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